TNF α Mechanically Sensitizes Masseter Muscle Nociceptors by 2 Increasing Prostaglandin E 2 Levels
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چکیده
1 TNFα Mechanically Sensitizes Masseter Muscle Nociceptors by 2 Increasing Prostaglandin E2 Levels. 3 4 5 Akhlaq W. Hakim, Xudong Dong, Brian E. Cairns 6 7 Faculty of Pharmaceutical Sciences, The University of British Columbia, Vancouver, British Columbia, 8 V6T 1Z3, Canada 9 10 11 12 13 14 Running title: TNFα-induced nociceptor sensitization 15 16 17 18 19 20 Correspondence should be addressed to: 21 22 Brian E. Cairns, RPh, ACPR, PhD 23 Faculty of Pharmaceutical Sciences 24 The University of British Columbia 25 2146 East Mall, Vancouver, British Columbia 26 V6T 1Z3 CANADA 27 Phone: 1-604-822-7715 28 Fax: 1-604-822-3035 29 Email: [email protected] 30 31
منابع مشابه
TNFα mechanically sensitizes masseter muscle nociceptors by increasing prostaglandin E2 levels.
TNFα induces mechanical sensitization of rat masseter muscle nociceptors, which takes 2-3 h to manifest and is mediated through activation of P55 and P75 receptors. This study was undertaken to determine whether TNFα induces nociceptor mechanical sensitization through the release of other algogenic substances such as glutamate, prostaglandin E(2) (PGE(2)), and/or nerve growth factor (NGF), whic...
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Hakim AW, Dong XD, Svensson P, Kumar U, Cairns BE. TNF mechanically sensitizes masseter muscle afferent fibers of male rats. J Neurophysiol 102: 1551–1559, 2009. First published June 24, 2009; doi:10.1152/jn.00326.2009. Behavioral evidence in rats indicates that injection of tumor necrosis factor alpha (TNF ) into skeletal muscle results in a prolonged mechanical sensitization without gross inf...
متن کاملTNFα Mechanically Sensitizes Masseter Muscle Afferent Fibers
1 2 TNFα Mechanically Sensitizes Masseter Muscle Afferent Fibers 3 of Male Rats 4 5 6 Akhlaq W. Hakim, Xu-Dong Dong, Peter Svensson, Ujendra Kumar, Brian E. Cairns 7 8 1 Faculty of Pharmaceutical Sciences, The University of British Columbia, Vancouver, British 9 Columbia, V6T 1Z3, Canada 10 2 Department of Clinical Oral Physiology, School of Dentistry, Århus University, DK-8000 11 Århus C, Denm...
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